Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25/09/21 08:30 | 25/09/21 08:30 | Manchester United | Aston Villa | 0:1 | 2 - 5 pontos |
| 25/09/21 08:30 | 25/09/21 08:30 | FC Chelsea | Manchester City | 0:1 | 2 - 5 pontos |
| 25/09/21 11:00 | 25/09/21 11:00 | Leeds United | West Ham United | 1:2 | 2 - 5 pontos |
| 25/09/21 11:00 | 25/09/21 11:00 | Leicester City | FC Burnley | 2:2 | 2 - 5 pontos |
| 25/09/21 11:00 | 25/09/21 11:00 | FC Watford | Newcastle United | 1:1 | 2 - 5 pontos |
| 25/09/21 11:00 | 25/09/21 11:00 | FC Everton | Norwich City | 2:0 | 2 - 5 pontos |
| 25/09/21 13:30 | 25/09/21 13:30 | Brentford FC | FC Liverpool | 3:3 | 2 - 5 pontos |
| 26/09/21 10:00 | 26/09/21 10:00 | FC Southampton | Wolverhampton Wanderers | 0:1 | 2 - 5 pontos |
| 26/09/21 12:30 | 26/09/21 12:30 | FC Arsenal | Tottenham Hotspurs | 3:1 | 2 - 5 pontos |
| 27/09/21 16:00 | 27/09/21 16:00 | Crystal Palace | Brighton and Hove Albion | 1:1 | 2 - 5 pontos |