Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17/09/21 16:00 | 17/09/21 16:00 | Celta Vigo | FC Cádiz | 1:2 | 3 - 6 - 6 |
| 18/09/21 09:00 | 18/09/21 09:00 | Rayo Vallecano | FC Getafe | 3:0 | 3 - 6 - 6 |
| 18/09/21 11:15 | 18/09/21 11:15 | Atlético Madrid | Athletic Bilbao | 0:0 | 3 - 6 - 6 |
| 18/09/21 13:30 | 18/09/21 13:30 | FC Elche | UD Levante | 1:1 | 4 - 6 - 4 |
| 18/09/21 16:00 | 18/09/21 16:00 | Deportivo Alavés | CA Osasuna | 0:2 | 4 - 4 - 5 |
| 19/09/21 09:00 | 19/09/21 09:00 | RCD Mallorca | FC Villarreal | 0:0 | 6 - 4 - 4 |
| 19/09/21 11:15 | 19/09/21 11:15 | Real Sociedad | FC Sevilla | 0:0 | 6 - 5 - 4 |
| 19/09/21 13:30 | 19/09/21 13:30 | Real Betis Sevilla | Espanyol Barcelona | 2:2 | 3 - 6 - 6 |
| 19/09/21 16:00 | 19/09/21 16:00 | FC Valencia | Real Madrid | 1:2 | 6 - 6 - 3 |
| 20/09/21 16:00 | 20/09/21 16:00 | FC Barcelona | FC Granada | 1:1 | 3 - 6 - 6 |