Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25/09/21 09:00 | 25/09/21 09:00 | Deportivo Alavés | Atlético Madrid | 1:0 | 6 - 6 - 3 |
| 25/09/21 11:15 | 25/09/21 11:15 | FC Valencia | Athletic Bilbao | 1:1 | 3 - 4 - 6 |
| 25/09/21 13:30 | 25/09/21 13:30 | FC Sevilla | Espanyol Barcelona | 2:0 | 3 - 6 - 6 |
| 25/09/21 16:00 | 25/09/21 16:00 | Real Madrid | FC Villarreal | 0:0 | 3 - 6 - 6 |
| 26/09/21 09:00 | 26/09/21 09:00 | RCD Mallorca | CA Osasuna | 2:3 | 5 - 4 - 4 |
| 26/09/21 11:15 | 26/09/21 11:15 | FC Barcelona | UD Levante | 3:0 | 3 - 6 - 6 |
| 26/09/21 13:30 | 26/09/21 13:30 | Real Sociedad | FC Elche | 1:0 | 3 - 6 - 6 |
| 26/09/21 13:30 | 26/09/21 13:30 | Rayo Vallecano | FC Cádiz | 3:1 | 3 - 6 - 6 |
| 26/09/21 16:00 | 26/09/21 16:00 | Real Betis Sevilla | FC Getafe | 2:0 | 3 - 5 - 6 |
| 27/09/21 16:00 | 27/09/21 16:00 | Celta Vigo | FC Granada | 1:0 | 4 - 4 - 6 |