| Eastern Conference | Jo | Pts | Gols | Dif | V | E | D | |
|---|---|---|---|---|---|---|---|---|
| 1. | Nashville SC | 30 | 67 | 64:23 | 41 | 20 | 7 | 3 |
| 2. | Inter Miami CF | 30 | 55 | 73:51 | 22 | 15 | 10 | 5 |
| 3. | New England Revolution | 30 | 52 | 49:41 | 8 | 16 | 4 | 10 |
| 4. | Chicago Fire | 30 | 48 | 52:44 | 8 | 14 | 6 | 10 |
| 5. | Charlotte FC | 30 | 47 | 53:45 | 8 | 13 | 8 | 9 |
| 6. | Philadelphia Union | 30 | 46 | 61:48 | 13 | 13 | 7 | 10 |
| 7. | Orlando City | 30 | 41 | 58:70 | -12 | 12 | 5 | 13 |
| 8. | Cincinnati FC | 30 | 39 | 62:71 | -9 | 10 | 9 | 11 |
| 9. | Toronto FC | 30 | 36 | 46:55 | -9 | 8 | 12 | 10 |
| 10. | New York Red Bulls | 30 | 36 | 39:56 | -17 | 10 | 6 | 14 |
| 11. | Columbus Crew | 30 | 35 | 46:47 | -1 | 10 | 5 | 15 |
| 12. | New York City FC | 30 | 34 | 43:41 | 2 | 8 | 10 | 12 |
| 13. | DC United | 30 | 33 | 38:53 | -15 | 7 | 12 | 11 |
| 14. | Atlanta United FC | 30 | 30 | 37:51 | -14 | 8 | 6 | 16 |
| 15. | CF Montreal | 30 | 25 | 36:60 | -24 | 6 | 7 | 17 |
| Western Conference | Jo | Pts | Gols | Dif | V | E | D | |
|---|---|---|---|---|---|---|---|---|
| 1. | Vancouver Whitecaps | 30 | 55 | 63:31 | 32 | 16 | 7 | 7 |
| 2. | St. Louis City SC | 30 | 51 | 56:41 | 15 | 14 | 9 | 7 |
| 3. | FC Dallas | 30 | 51 | 55:47 | 8 | 14 | 9 | 7 |
| 4. | San Jose Earthquakes | 30 | 48 | 52:42 | 10 | 13 | 9 | 8 |
| 5. | Houston Dynamo | 30 | 47 | 41:39 | 2 | 13 | 8 | 9 |
| 6. | Los Angeles FC | 31 | 46 | 48:33 | 15 | 12 | 10 | 9 |
| 7. | Seattle Sounders | 30 | 42 | 39:37 | 2 | 11 | 9 | 10 |
| 8. | Los Angeles Galaxy | 31 | 40 | 43:52 | -9 | 10 | 10 | 11 |
| 9. | Colorado Rapids | 30 | 39 | 41:41 | 0 | 11 | 6 | 13 |
| 10. | Real Salt Lake | 30 | 36 | 45:48 | -3 | 10 | 6 | 14 |
| 11. | San Diego FC | 30 | 34 | 53:56 | -3 | 8 | 10 | 12 |
| 12. | Portland Timbers | 30 | 34 | 51:56 | -5 | 9 | 7 | 14 |
| 13. | Minnesota United FC | 30 | 34 | 47:55 | -8 | 8 | 10 | 12 |
| 14. | Austin FC | 30 | 31 | 38:56 | -18 | 7 | 10 | 13 |
| 15. | Sporting Kansas City | 30 | 22 | 36:75 | -39 | 6 | 4 | 20 |